Epistasis at the SARS-CoV-2 Receptor-Binding Domain Interface and the Propitiously Boring Implications for Vaccine Escape
Name
mbio.00135-22.pdf
Description
Published version
Size
2.48 MB
Format
Adobe PDF
Checksum (MD5)
6116b1859cef0f0825625ad606afa750
Author(s)
Rochman, Nash D
Faure, Guilhem
Wolf, Yuri I
Freddolino, Peter L
Zhang, Feng
Koonin, Eugene V
Date Issued
April 26, 2022
Journal
mBio
Publisher
American Society for Microbiology
Citation
Rochman, Nash D, Faure, Guilhem, Wolf, Yuri I, Freddolino, Peter L, Zhang, Feng et al. 2022. "Epistasis at the SARS-CoV-2 Receptor-Binding Domain Interface and the Propitiously Boring Implications for Vaccine Escape." mBio, 13 (2).
Version
Final published version
Abstract
Emergence of vaccine escape variants of SARS-CoV-2 is arguably the most pressing problem during the COVID-19 pandemic as vaccines are distributed worldwide. We employed a computational approach to assess the risk of antibody escape resulting from mutations in the receptor-binding domain of the spike protein of the wild-type SARS-CoV-2 virus as well as the Delta, Gamma, and Omicron variants.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Terms of Use
Creative Commons Attribution
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1128/mbio.00135-22
