An Epigenetic Signature for Monoallelic Olfactory Receptor Expression
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Kellis_An epigenetic.pdf
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Author(s)
Magklara, Angeliki
Yen, Angela
Colquitt, Bradley M.
Clowney, E. Josephine
Allen, William
Markenscoff-Papadimitriou, Eirene
Evans, Zoe A.
Kheradpour, Pouya
Mountoufaris, George
Carey, Catriona
Date Issued
May 2011
Journal
Cell
Publisher
Elsevier B.V.
Citation
Magklara, Angeliki, Angela Yen, Bradley M. Colquitt, E. Josephine Clowney, William Allen, Eirene Markenscoff-Papadimitriou, Zoe A. Evans, et al. “An Epigenetic Signature for Monoallelic Olfactory Receptor Expression.” Cell 145, no. 4 (May 2011): 555–570. © 2011 Elsevier.
Version
Final published version
Abstract
Constitutive heterochromatin is traditionally viewed as the static form of heterochromatin that silences pericentromeric and telomeric repeats in a cell cycle- and differentiation-independent manner. Here, we show that, in the mouse olfactory epithelium, olfactory receptor (OR) genes are marked in a highly dynamic fashion with the molecular hallmarks of constitutive heterochromatin, H3K9me3 and H4K20me3. The cell type and developmentally dependent deposition of these marks along the OR clusters are, most likely, reversed during the process of OR choice to allow for monogenic and monoallelic OR expression. In contrast to the current view of OR choice, our data suggest that OR silencing takes place before OR expression, indicating that it is not the product of an OR-elicited feedback signal. Our findings suggest that chromatin-mediated silencing lays a molecular foundation upon which singular and stochastic selection for gene expression can be applied.
MIT Department
Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1016/j.cell.2011.03.040
