Toward a Common Coordinate Framework for the Human Body
Name
nihms-1545970.pdf
Description
Accepted version
Size
1.34 MB
Format
Adobe PDF
Checksum (MD5)
a8a214881714ff7ec88624adf3507042
Author(s)
Regev, Aviv
Date Issued
December 2019
Journal
Cell
Publisher
Elsevier BV
Citation
Rood, Jennifer E. et al. “Toward a Common Coordinate Framework for the Human Body.” Cell, 179, 7 (December 2019): 1455–1467 © 2019 The Author(s)
Version
Author's final manuscript
Abstract
Understanding the genetic and molecular drivers of phenotypic heterogeneity across individuals is central to biology. As new technologies enable fine-grained and spatially resolved molecular profiling, we need new computational approaches to integrate data from the same organ across different individuals into a consistent reference and to construct maps of molecular and cellular organization at histological and anatomical scales. Here, we review previous efforts and discuss challenges involved in establishing such a common coordinate framework, the underlying map of tissues and organs. We focus on strategies to handle anatomical variation across individuals and highlight the need for new technologies and analytical methods spanning multiple hierarchical scales of spatial resolution.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.CELL.2019.11.019
