A microneedle platform for buccal macromolecule delivery
Name
eabe2620.full.pdf
Description
Published version
Size
2.93 MB
Format
Adobe PDF
Checksum (MD5)
076b01d01adf12b00ba63492d034e85c
Author(s)
Caffarel-Salvador, Ester
Kim, Soyoung
Soares, Vance
Tian, Ryan Yu
Stern, Sarah R
Minahan, Daniel
Yona, Raissa
Lu, Xiaoya
Zakaria, Fauziah R
Collins, Joy
Date Issued
2021
Journal
Science Advances
Publisher
American Association for the Advancement of Science (AAAS)
Version
Final published version
Abstract
© 2021 American Association for the Advancement of Science. All rights reserved. Alternative means for drug delivery are needed to facilitate drug adherence and administration. Microneedles (MNs) have been previously investigated transdermally for drug delivery. To date, drug loading into MNs has been limited by drug solubility in the polymeric blend. We designed a highly drug-loaded MN patch to deliver macromolecules and applied it to the buccal area, which allows for faster delivery than the skin. We successfully delivered 1-mg payloads of human insulin and human growth hormone to the buccal cavity of swine within 30 s. In addition, we conducted a trial in 100 healthy volunteers to assess potential discomfort associated with MNs when applied in the oral cavity, identifying the hard palate as the preferred application site. We envisage that MN patches applied on buccal surfaces could increase medication adherence and facilitate the painless delivery of biologics and other drugs to many, especially r the pediatric and elderly populations.
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
Massachusetts Institute of Technology. Division of Comparative Medicine
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Research Laboratory of Electronics
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
Creative Commons Attribution NonCommercial License 4.0
Persistent DSpace Link
DOI of Published Version
10.1126/sciadv.abe2620
https://doi.org/10.1126/sciadv.abe2620
