Static and dynamic light scattering of healthy and malaria-parasite blood cells
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Park-2010-Static and dynamic l.pdf
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Checksum (MD5)
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Author(s)
Suresh, Subra
Park, YongKeun
Diez Silva, Monica
Fu, Dan
Barman, Ishan
Feld, Michael S.
Popescu, Gabriel
Choi, Wonshik
Date Issued
April 2010
Journal
Journal of Biomedical Optics
Publisher
Society of Photo-optical Instrumentation Engineers
Citation
Park, YongKeun et al. “Static and dynamic light scattering of healthy and malaria-parasite invaded red blood cells.” Journal of Biomedical Optics 15.2 (2010): 020506-3.©2010 Society of Photo-Optical Instrumentation Engineers.
Version
Final published version
Abstract
We present the light scattering of individual Plasmodium falciparum-parasitized human red blood cells (Pf-RBCs), and demonstrate progressive alterations to the scattering signal arising from the development of malaria-inducing parasites. By selectively imaging the electric fields using quantitative phase microscopy and a Fourier transform light scattering technique, we calculate the light scattering maps of individual Pf-RBCs. We show that the onset and progression of pathological states of the Pf-RBCs can be clearly identified by the static scattering maps. Progressive changes to the biophysical properties of the Pf-RBC membrane are captured from dynamic light scattering.
MIT Department
Massachusetts Institute of Technology. Department of Materials Science and Engineering
Massachusetts Institute of Technology. Department of Mechanical Engineering
Massachusetts Institute of Technology. School of Engineering
Massachusetts Institute of Technology. Spectroscopy Laboratory
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1117/1.3369966
