Techniques for the characterization of sedation due to opiate administration
Name
1102057211-MIT.pdf
Size
10.49 MB
Format
Adobe PDF
Checksum (MD5)
4f2a524ff565c9c988ec00b247fb3af5
Author(s)
Mullen, Andrew Carter.
Advisor(s)
Patrick L. Purdon and Emery N. Brown.
Date Issued
2019
Publisher
Massachusetts Institute of Technology
Abstract
The focus of this thesis is identifying human physiologic markers during opiate sedation for applications in general anesthesia and drug overdose. Under this central topic, three themes are developed: characterizing the neural signature associated with altered consciousness due to opiate administration, characterizing the diminished respiration and behavioral effects of sedation due to opiate administration, and correlating these features. This work led to the development of signal processing techniques using state-space autoregressive equations to model respiratory data. Additionally, this project required designing and conducting a clinical experiment at the Massachusetts General Hospital with the permission of the Partners Institutional Review Board and the guidance of the Anesthesia, Critical Care, and Pain Management department at the Massachusetts General Hospital. The data used in this investigation were collected in the operating rooms at the Massachusetts General Hospital with the help of anesthesiologists, surgeons, nursing staff, and clinical research coordinators.
Description
This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2019
Cataloged from student-submitted PDF version of thesis.
Includes bibliographical references (pages 69-71).
Subjects
Electrical Engineering and Computer Science.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
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