Accelerating Palladium-Catalyzed C-F Bond Formation: Use of a Microflow Packed-Bed Reactor
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Buchwald_Accelerating palladium.pdf
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1.96 MB
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Author(s)
Maimone, Thomas
Noel, Timothy
Buchwald, Stephen Leffler
Date Issued
August 2011
Journal
Angewandte Chemie International Edition
Publisher
Wiley Blackwell
Citation
Noël, Timothy, Thomas J. Maimone, and Stephen L. Buchwald. “Accelerating Palladium-Catalyzed C-F Bond Formation: Use of a Microflow Packed-Bed Reactor.” Angewandte Chemie International Edition 50, no. 38 (September 12, 2011): 8900-8903.
Version
Author's final manuscript
Abstract
A flow process for Pd-catalyzed C-F bond formation is described. A microreactor with a packed-bed design allows for easy handling of large quantities of insoluble CsF with precise control over reaction times, efficient mixing, and the ability to safely handle elevated temperatures and pressures. A variety of aryl triflates, including heteroaryl ones, were converted into aryl fluorides in short reaction times (see scheme).
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1002/anie.201104652
