Cell Type-Specific Transcriptomics Reveals that Mutant Huntingtin Leads to Mitochondrial RNA Release and Neuronal Innate Immune Activation
Name
nihms-1608606.pdf
Description
Accepted version
Size
3.08 MB
Format
Adobe PDF
Checksum (MD5)
44764ceec7652065f4e503b280ac19b9
Author(s)
Lee, Hyeseung
Fenster, Robert J
Pineda, S Sebastian
Gibbs, Whitney S
Mohammadi, Shahin
Davila-Velderrain, Jose
Garcia, Francisco J
Therrien, Martine
Novis, Hailey S
Gao, Fan
Date Issued
2020
Journal
Neuron
Publisher
Elsevier BV
Version
Author's final manuscript
Abstract
Lee, Fenster, et al. conduct striatal cell type-specific transcriptomics in mouse models of HD and human HD. Their findings reveal that mutant huntingtin leads to the release of mitochondrial RNAs and activation of innate immune signaling in neurons in a manner that correlates with striatal cell vulnerability in HD.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.NEURON.2020.06.021
