Liver ‘organ on a chip’
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nihms964762.pdf
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Checksum (MD5)
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Author(s)
Beckwitt, Colin H.
Clark, Amanda M.
Wheeler, Sarah
Taylor, D. Lansing
Stolz, Donna B.
Wells, Alan
Griffith, Linda G
Date Issued
December 2017
Journal
Experimental Cell Research
Publisher
Elsevier BV
Citation
Beckwitt, Colin H. et al. “Liver ‘organ on a Chip.’” Experimental Cell Research 363, 1 (February 2018): 15–25 © 2017 Elsevier
Version
Author's final manuscript
Abstract
© 2017 The liver plays critical roles in both homeostasis and pathology. It is the major site of drug metabolism in the body and, as such, a common target for drug-induced toxicity and is susceptible to a wide range of diseases. In contrast to other solid organs, the liver possesses the unique ability to regenerate. The physiological importance and plasticity of this organ make it a crucial system of study to better understand human physiology, disease, and response to exogenous compounds. These aspects have impelled many to develop liver tissue systems for study in isolation outside the body. Herein, we discuss these biologically engineered organoids and microphysiological systems. Keywords: Microphysiologic systems; Organoids; 3D culture systems
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.YEXCR.2017.12.023
