Mechanisms of DNA damage‐mediated neurotoxicity in neurodegenerative disease
Name
EMBO Reports - 2022 - Welch - Mechanisms of DNA damage‐mediated neurotoxicity in neurodegenerative disease.pdf
Description
Published version
Size
998.63 KB
Format
Adobe PDF
Checksum (MD5)
b611ccba24fc456e3faee4ee065c7886
Author(s)
Welch, Gwyneth
Tsai, Li‐Huei
Date Issued
June 7, 2022
Journal
EMBO reports
Publisher
EMBO
Citation
Welch, Gwyneth and Tsai, Li‐Huei. 2022. "Mechanisms of DNA damage‐mediated neurotoxicity in neurodegenerative disease." EMBO reports, 23 (6).
Version
Final published version
Abstract
Neurons are highly susceptible to DNA damage accumulation due to their large energy requirements, elevated transcriptional activity, and long lifespan. While newer research has shown that DNA breaks and mutations may facilitate neuron diversity during development and neuronal function throughout life, a wealth of evidence indicates deficient DNA damage repair underlies many neurological disorders, especially age-associated neurodegenerative diseases. Recently, efforts to clarify the molecular link between DNA damage and neurodegeneration have improved our understanding of how the genomic location of DNA damage and defunct repair proteins impact neuron health. Additionally, work establishing a role for senescence in the aging and diseased brain reveals DNA damage may play a central role in neuroinflammation associated with neurodegenerative disease.
MIT Department
Picower Institute for Learning and Memory
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
10.15252/embr.202154217
