Epidemiological and Immunological Features of Obesity and SARS-CoV-2
Name
viruses-13-02235-v2.pdf
Size
3.45 MB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Nilles, Eric J.
Siddiqui, Sameed M.
Fischinger, Stephanie
Bartsch, Yannic C.
de St. Aubin, Michael
Zhou, Guohai
Gluck, Matthew J.
Berger, Samuel
Rhee, Justin
Petersen, Eric
Date Issued
November 6, 2021
Journal
Viruses
Publisher
Multidisciplinary Digital Publishing Institute
Citation
Viruses 13 (11): 2235 (2021)
Version
Final published version
Abstract
Obesity is a key correlate of severe SARS-CoV-2 outcomes while the role of obesity on risk of SARS-CoV-2 infection, symptom phenotype, and immune response remain poorly defined. We examined data from a prospective SARS-CoV-2 cohort study to address these questions. Serostatus, body mass index, demographics, comorbidities, and prior COVID-19 compatible symptoms were assessed at baseline and serostatus and symptoms monthly thereafter. SARS-CoV-2 immunoassays included an IgG ELISA targeting the spike RBD, multiarray Luminex targeting 20 viral antigens, pseudovirus neutralization, and T cell ELISPOT assays. Our results from a large prospective SARS-CoV-2 cohort study indicate symptom phenotype is strongly influenced by obesity among younger but not older age groups; we did not identify evidence to suggest obese individuals are at higher risk of SARS-CoV-2 infection; and remarkably homogenous immune activity across BMI categories suggests immune protection across these groups may be similar.
MIT Department
Massachusetts Institute of Technology. Computational and Systems Biology Program
Ragon Institute of MGH, MIT and Harvard
Massachusetts Institute of Technology. Department of Biological Engineering
Terms of Use
Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.3390/v13112235
