Lipid-Like Nanomaterials for Simultaneous Gene Expression and Silencing In Vivo
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Anderson_Lipid-like nanomaterials.pdf
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Author(s)
Dong, Yizhou
Eltoukhy, Ahmed A.
Alabi, Christopher A.
Veiseh, Omid
Sirirungruang, Sasilada
Yin, Hao
Tang, Benjamin C.
Chen, Delai
Gu, Zhen
Xue, Yuan
Date Issued
March 2014
Journal
Advanced Healthcare Materials
Publisher
Wiley Blackwell
Citation
Dong, Yizhou, Ahmed A. Eltoukhy, Christopher A. Alabi, Omar F. Khan, Omid Veiseh, J. Robert Dorkin, Sasilada Sirirungruang, et al. “Lipid-Like Nanomaterials for Simultaneous Gene Expression and Silencing In Vivo.” Adv. Healthcare Mater. 3, no. 9 (March 13, 2014): 1392–1397.
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Author's final manuscript
Abstract
New lipid-like nanomaterials are developed to simultaneously regulate expression of multiple genes. Self-assembled nanoparticles are capable of efficiently encapsulating pDNA and siRNA. These nanoparticles are shown to induce simultaneous gene expression and silencing both in vitro and in vivo.
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Department of Chemistry
Koch Institute for Integrative Cancer Research at MIT
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DOI of Published Version
https://doi.org/10.1002/adhm.201400054
