Functional anatomy of neural circuits regulating fear and extinction
Name
Knapska-2012-Functional anatomy of neural circuits regulating fear and extinction.pdf
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653.61 KB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Sheng, Morgan Hwa-Tze
Knapska, Ewelina
Macias, Matylda
Mikosz, Marta
Nowak, Aleksandra
Owczarek, Dorota
Wawrzyniak, Marcin
Pieprzyk, Marcelina
Cymerman, Iwona A.
Werka, Tomasz
Date Issued
October 2012
Journal
Proceedings of the National Academy of Sciences of the United States of America
Publisher
National Academy of Sciences (U.S.)
Citation
Knapska, E. et al. “Functional Anatomy of Neural Circuits Regulating Fear and Extinction.” Proceedings of the National Academy of Sciences 109.42 (2012): 17093–17098. ©2013 National Academy of Sciences
Version
Final published version
Abstract
The memory of fear extinction is context dependent: fear that is suppressed in one context readily renews in another. Understanding of the underlying neuronal circuits is, therefore, of considerable clinical relevance for anxiety disorders. Prefrontal cortical and hippocampal inputs to the amygdala have recently been shown to regulate the retrieval of fear memories, but the cellular organization of these projections remains unclear. By using anterograde tracing in a transgenic rat in which neurons express a dendritically-targeted PSD-95:Venus fusion protein under the control of a c-fos promoter, we found that, during the retrieval of extinction memory, the dominant input to active neurons in the lateral amygdala was from the infralimbic cortex, whereas the retrieval of fear memory was associated with greater hippocampal and prelimbic inputs. This pattern of retrieval-related afferent input was absent in the central nucleus of the amygdala. Our data show functional anatomy of neural circuits regulating fear and extinction, providing a framework for therapeutic manipulations of these circuits.
MIT Department
Picower Institute for Learning and Memory
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1073/pnas.1202087109
