Four-Dimensional (Bio-)printing: A Review on Stimuli-Responsive Mechanisms and Their Biomedical Suitability
Name
applsci-10-09143-v2.pdf
Size
4.29 MB
Format
Adobe PDF
Checksum (MD5)
f66d83a8efbe954804a98a233fc8c867
Author(s)
Morouço, Pedro
Azimi, Bahareh
Milazzo, Mario
Mokhtari, Fatemeh
Fernandes, Cristiana
Reis, Diana
Danti, Serena
Date Issued
December 2020
Journal
Applied Sciences
Publisher
MDPI AG
Citation
Morouço, Pedro et al. "Four-Dimensional (Bio-)printing: A Review on Stimuli-Responsive Mechanisms and Their Biomedical Suitability." Applied Sciences 10, 24 (December 2020): 9143 © 2020 The Authors
Version
Final published version
Abstract
The applications of tissue engineered constructs have witnessed great advances in the last few years, as advanced fabrication techniques have enabled promising approaches to develop structures and devices for biomedical uses. (Bio-)printing, including both plain material and cell/material printing, offers remarkable advantages and versatility to produce multilateral and cell-laden tissue constructs; however, it has often revealed to be insufficient to fulfill clinical needs. Indeed, three-dimensional (3D) (bio-)printing does not provide one critical element, fundamental to mimic native live tissues, i.e., the ability to change shape/properties with time to respond to microenvironmental stimuli in a personalized manner. This capability is in charge of the so-called “smart materials”; thus, 3D (bio-)printing these biomaterials is a possible way to reach four-dimensional (4D) (bio-)printing. We present a comprehensive review on stimuli-responsive materials to produce scaffolds and constructs via additive manufacturing techniques, aiming to obtain constructs that closely mimic the dynamics of native tissues. Our work deploys the advantages and drawbacks of the mechanisms used to produce stimuli-responsive constructs, using a classification based on the target stimulus: humidity, temperature, electricity, magnetism, light, pH, among others. A deep understanding of biomaterial properties, the scaffolding technologies, and the implant site microenvironment would help the design of innovative devices suitable and valuable for many biomedical applications.
MIT Department
Massachusetts Institute of Technology. Department of Civil and Environmental Engineering
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Creative Commons Attribution
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.3390/app10249143
