Clustered Dynamics of Inhibitory Synapses and Dendritic Spines in the Adult Neocortex
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Chen-2012-Clustered Dynamics o.pdf
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Author(s)
Chen, Jerry L.
Villa, Katherine Leigh
Cha, Jae Won
So, Peter T. C.
Kubota, Yoshiyuki
Nedivi, Elly
Date Issued
April 2012
Journal
Neuron
Publisher
Elsevier B.V.
Citation
Chen, Jerry L., Katherine L. Villa, Jae Won Cha, Peter T.C. So, Yoshiyuki Kubota, and Elly Nedivi. “Clustered Dynamics of Inhibitory Synapses and Dendritic Spines in the Adult Neocortex.” Neuron 74, no. 2 (April 2012): 361–373. © 2012 Elsevier Inc.
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Final published version
Abstract
A key feature of the mammalian brain is its capacity to adapt in response to experience, in part by remodeling of synaptic connections between neurons. Excitatory synapse rearrangements have been monitored in vivo by observation of dendritic spine dynamics, but lack of a vital marker for inhibitory synapses has precluded their observation. Here, we simultaneously monitor in vivo inhibitory synapse and dendritic spine dynamics across the entire dendritic arbor of pyramidal neurons in the adult mammalian cortex using large-volume, high-resolution dual-color two-photon microscopy. We find that inhibitory synapses on dendritic shafts and spines differ in their distribution across the arbor and in their remodeling kinetics during normal and altered sensory experience. Further, we find inhibitory synapse and dendritic spine remodeling to be spatially clustered and that clustering is influenced by sensory input. Our findings provide in vivo evidence for local coordination of inhibitory and excitatory synaptic rearrangements.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Massachusetts Institute of Technology. Department of Mechanical Engineering
Picower Institute for Learning and Memory
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1016/j.neuron.2012.02.030
