Synthesis and development of hydrophilic iron oxide nanoparticles for biomedical applications
Name
905969154-MIT.pdf
Description
Full printable version
Size
19.37 MB
Format
Adobe PDF
Checksum (MD5)
da230ca5a7d832125c10a13693262eb8
Author(s)
Wei, He, Ph.D. Massachusetts Institute of Technology
Advisor(s)
Moungi G. Bawendi.
Date Issued
2014
Publisher
Massachusetts Institute of Technology
Abstract
Uniformly sized superparamagnetic iron oxide nanoparticles (SPIONs) with inorganic diameters of 3-35 nm were synthesized. New surface ligand coatings were designed and synthesized, and the resulting hydrophilic SPIONs in biological buffers were found to be compact, stable, highly magnetic, and biocompatible. Furthermore, the hydrophilic SPIONs were stable in vitro in serums and cells as well as in vivo in mice. Functionalized SPIONs demonstrated the ability of specific labeling. Finally, the hydrophilic SPIONs have potential as a non-toxic alternative to Gadolinium based contrast agents for T₁-weighted magnetic resonance imaging (MRI) and they have shown potential in multicolor MRI as well as magnetic particle imaging.
Description
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 2014.
Cataloged from PDF version of thesis. Vita.
Includes bibliographical references (pages 130-136).
Subjects
Chemistry.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Terms of Use
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