Are redox changes a critical switch for mitotic progression?
Name
KMCO_7_1832419.pdf
Description
Published version
Size
1.03 MB
Format
Unknown
Checksum (MD5)
04f5a41bc2b755a688ede2ef0df361da
Author(s)
Lim, Daniel Cham-Chin
Joukov, Vladimir
Yaffe, Michael B
Date Issued
2020
Journal
Molecular and Cellular Oncology
Publisher
Informa UK Limited
Version
Final published version
Abstract
Cell-cycle dependent redox changes result in increased protein oxidation in mitotic cells. We show that oxidative modifications of a conserved cysteine residue within Aurora A kinase (AURKA) can promote its activation during mitosis. Targeting redox-sensitive cysteine residues within AURKA may lead to the development of novel anti-cancer agents with improved clinical efficacy.
MIT Department
Center for Precision Cancer Medicine
Koch Institute for Integrative Cancer Research at MIT
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1080/23723556.2020.1832419
