Electroceuticals in the Gastrointestinal Tract
Name
nihms-1676822.pdf
Description
Accepted version
Size
935.37 KB
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Unknown
Checksum (MD5)
9dd4f7b91f8c0c1b60936bb2b479280b
Author(s)
Ramadi, Khalil B
Srinivasan, Shriya S
Traverso, Giovanni
Date Issued
October 2020
Journal
Trends in Pharmacological Sciences
Publisher
Elsevier BV
Citation
Ramadi, Khalil B, Srinivasan, Shriya S and Traverso, Giovanni. 2020. "Electroceuticals in the Gastrointestinal Tract." Trends in Pharmacological Sciences, 41 (12).
Version
Author's final manuscript
Abstract
The field of electroceuticals has attracted considerable attention over the past few decades as a novel therapeutic modality. The gastrointestinal (GI) tract (GIT) holds significant potential as a target for electroceuticals as the intersection of neural, endocrine, and immune systems. We review recent developments in electrical stimulation of various portions of the GIT (including esophagus, stomach, and small and large intestine) and nerves projecting to the GIT and supportive organs. This has been tested with varying degrees of success for several dysmotility, inflammatory, hormonal, and neurologic disorders. We outline a vision for the future of GI electroceuticals, building on advances in mechanistic understanding of GI physiology coupled with novel ingestible technologies. The next wave of electroceutical therapies will be minimally invasive and more targeted than current approaches, making them an indispensable tool in the clinical armamentarium.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.TIPS.2020.09.014
