Externally Tunable, Low Power Electrostatic Control of Cell Adhesion with Nanometric High‐k Dielectric Films
Name
Adv Funct Materials - 2023 - Leon - Externally Tunable Low Power Electrostatic Control of Cell Adhesion with Nanometric.pdf
Description
Published version
Size
1.46 MB
Format
Adobe PDF
Checksum (MD5)
f1d99416af5f74496a5e889a9e92a0a3
Author(s)
Leon, Victor J.
Blanc, Baptiste
Sonnert, Sophia D.
Varanasi, Kripa K.
Date Issued
April 13, 2023
Journal
Advanced Functional Materials
Publisher
Wiley
Citation
V. J. Leon, B. Blanc, S. D. Sonnert, K. K. Varanasi, Externally Tunable, Low Power Electrostatic Control of Cell Adhesion with Nanometric High-k Dielectric Films. Adv. Funct. Mater. 2023, 33, 2300732.
Version
Final published version
Abstract
Controlling cell adhesion to surfaces is an important, but difficult, problem. Current methods to control adhesion rely on surface functionalization, which have limited material choice to avoid cell toxicity and are typically cell specific. Herein, cell adhesion is modulated by using nanometric high‐k dielectric films. Voltage is applied across the dielectric film, changing the film surface's zeta potential, ζ. High performance dielectrics, HfO2 and SiO2, enables a change in the ζ polarity and magnitude over large, 100 mV, ranges by applying ≈1 V across the dielectrics with ≈1nW power draw. Freshwater Chlorella vulgaris and saltwater Nannochloropsis oculata, which have a negative ζ, are used as model cells. Cell adhesion is observed to be inhibited when both surface and cell ζ are negative and enhanced when surface ζ is positive and cell ζ are negative using microfluidic experiments. Finally, millimetric scale cell patterning is demonstrated by spatially modulating ζ with no observed toxicity to cells over 4 weeks.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1002/adfm.202300732
