Targeting microRNAs in obesity
Name
Lodish_Targeting microRNAs.pdf
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685.93 KB
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Adobe PDF
Checksum (MD5)
9b83a1516ba295c76c3fcbaca4c974e9
Author(s)
Xie, Huangming
Sun, Lei
Lodish, Harvey F
Date Issued
October 2009
Journal
Expert Opinion on Therapeutic Targets
Publisher
Informa Healthcare
Citation
Xie, Huangming, Lei Sun, and Harvey F Lodish. “Targeting microRNAs in Obesity.” Expert Opinion on Therapeutic Targets 13.10 (2009): 1227–1238.
Version
Author's final manuscript
Abstract
Obesity is a serious health problem worldwide associated with an increased risk of life-threatening diseases such as type 2 diabetes, atherosclerosis, and certain types of cancer. Fundamental for the development of novel therapeutics for obesity and its associated metabolic syndromes is an understanding of the regulation of fat cell development. Recent computational and experimental studies have shown that microRNAs (miRNAs) play a role in metabolic tissue development, lipid metabolism and glucose homeostasis. In addition, many miRNAs are dysregulated in metabolic tissues from obese animals and humans, which potentially contributes to the pathogenesis of obesity-associated complications. In this review we summarize the current state of understanding of the roles of miRNAs in metabolic tissues under normal development and obese conditions, and discuss the potential use of miRNAs as therapeutic targets.
Description
Author Manuscript 2011 October 20.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Chemistry
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1517/14728220903190707
