A General, Practical Palladium-Catalyzed Cyanation of (Hetero)Aryl Chlorides and Bromides
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Author(s)
Senecal, Todd D.
Shu, Wei
Buchwald, Stephen Leffler
Date Issued
August 2013
Journal
Angewandte Chemie International Edition
Publisher
Wiley Blackwell
Citation
Senecal, Todd D., Wei Shu, and Stephen L. Buchwald. “A General, Practical Palladium-Catalyzed Cyanation of (Hetero)Aryl Chlorides and Bromides.” Angewandte Chemie International Edition 52, no. 38 (August 9, 2013): 10035–10039.
Version
Author's final manuscript
Abstract
Playing it safe: The nontoxic cyanide source K[subscript 4][Fe(CN)[subscript 6]⋅3 H[subscript 2]O can be used for the cyanation of (hetero)aryl halides. The application of palladacycle catalysts prevents poisoning during catalyst formation, thereby allowing for low catalyst loadings, fast reaction times, and wide heterocyclic substrate scope.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1002/anie.201304188
