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Putative protective neural mechanisms in prereaders with a family history of dyslexia who subsequently develop typical reading skills
Name
hbm.24980.pdf
Description
Published version
Size
2.27 MB
Format
Adobe PDF
Checksum (MD5)
99340289c27d98b1e8a86a932d3642c7
Author(s)
Yu, Xi
Zuk, Jennifer
Perdue, Meaghan V.
Ozernov-Palchik, Ola
Raney, Talia
Beach, Sara Dawley
Norton, Elizabeth S.
Ou, Yangming
Gabrieli, John D. E.
Gaab, Nadine
Date Issued
March 2020
Journal
Human Brain Mapping
Publisher
Wiley
Citation
Yu, Xi et al. "Putative protective neural mechanisms in prereaders with a family history of dyslexia who subsequently develop typical reading skills." Human Brain Mapping 41, 10 (March 2020): 2827-2845 © 2020 The Authors
Version
Final published version
Abstract
Human Brain Mapping published by Wiley Periodicals, Inc. Developmental dyslexia affects 40–60% of children with a familial risk (FHD+) compared to a general prevalence of 5–10%. Despite the increased risk, about half of FHD+ children develop typical reading abilities (FHD+Typical). Yet the underlying neural characteristics of favorable reading outcomes in at-risk children remain unknown. Utilizing a retrospective, longitudinal approach, this study examined whether putative protective neural mechanisms can be observed in FHD+Typical at the prereading stage. Functional and structural brain characteristics were examined in 47 FHD+ prereaders who subsequently developed typical (n = 35) or impaired (n = 12) reading abilities and 34 controls (FHD−Typical). Searchlight-based multivariate pattern analyses identified distinct activation patterns during phonological processing between FHD+Typical and FHD−Typical in right inferior frontal gyrus (RIFG) and left temporo-parietal cortex (LTPC) regions. Follow-up analyses on group-specific classification patterns demonstrated LTPC hypoactivation in FHD+Typical compared to FHD−Typical, suggesting this neural characteristic as an FHD+ phenotype. In contrast, RIFG showed hyperactivation in FHD+Typical than FHD−Typical, and its activation pattern was positively correlated with subsequent reading abilities in FHD+ but not controls (FHD−Typical). RIFG hyperactivation in FHD+Typical was further associated with increased interhemispheric functional and structural connectivity. These results suggest that some protective neural mechanisms are already established in FHD+Typical prereaders supporting their typical reading development.
MIT Department
McGovern Institute for Brain Research at MIT
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
http://dx.doi.org/10.1002/hbm.24980
