Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates
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Anderson_Size and shape.pdf
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Author(s)
Veiseh, Omid
Ma, Minglin
Tam, Hok Hei
Li, Jie
Langan, Erin
Wyckoff, Jeffrey
Loo, Whitney S.
Jhunjhunwala, Siddharth
Chiu, Alan
Tang, Katherine
Date Issued
May 2015
Journal
Nature Materials
Publisher
Nature Publishing Group
Citation
Veiseh, Omid, Joshua C. Doloff, Minglin Ma, Arturo J. Vegas, Hok Hei Tam, Andrew R. Bader, Jie Li, et al. “Size- and Shape-Dependent Foreign Body Immune Response to Materials Implanted in Rodents and Non-Human Primates.” Nature Materials 14, no. 6 (May 18, 2015): 643–51.
Version
Author's final manuscript
Abstract
The efficacy of implanted biomedical devices is often compromised by host recognition and subsequent foreign body responses. Here, we demonstrate the role of the geometry of implanted materials on their biocompatibility in vivo. In rodent and non-human primate animal models, implanted spheres 1.5 mm and above in diameter across a broad spectrum of materials, including hydrogels, ceramics, metals and plastics, significantly abrogated foreign body reactions and fibrosis when compared with smaller spheres. We also show that for encapsulated rat pancreatic islet cells transplanted into streptozotocin-treated diabetic C57BL/6 mice, islets prepared in 1.5-mm alginate capsules were able to restore blood-glucose control for up to 180 days, a period more than five times longer than for transplanted grafts encapsulated within conventionally sized 0.5-mm alginate capsules. Our findings suggest that the in vivo biocompatibility of biomedical devices can be significantly improved simply by tuning their spherical dimensions.
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
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DOI of Published Version
https://doi.org/10.1038/nmat4290
