The influence of T cell development on pathogen specificity and autoreactivity
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Chakraborty_Influence of T.pdf
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Author(s)
Kosmrlj, Andrej
Kardar, Mehran
Chakraborty, Arup K.
Date Issued
October 2012
Journal
Journal of Statistical Physics
Publisher
Springer-Verlag
Citation
Košmrlj, Andrej, Mehran Kardar, and Arup K. Chakraborty. “The Influence of T Cell Development on Pathogen Specificity and Autoreactivity.” Journal of Statistical Physics 149.2 (2011): 203–219.
Version
Author's final manuscript
Abstract
T cells orchestrate adaptive immune responses upon activation. T cell activation requires sufficiently strong binding of T cell receptors on their surface to short peptides derived from foreign proteins bound to protein products of the major histocompatibility (MHC) gene products, which are displayed on the surface of antigen presenting cells. T cells can also interact with peptide-MHC complexes, where the peptide is derived from host (self) proteins. A diverse repertoire of relatively self-tolerant T cell receptors is selected in the thymus. We study a model, computationally and analytically, to describe how thymic selection shapes the repertoire of T cell receptors, such that T cell receptor recognition of pathogenic peptides is both specific and degenerate. We also discuss the escape probability of autoimmune T cells from the thymus.
MIT Department
Institute for Medical Engineering and Science
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Department of Chemistry
Massachusetts Institute of Technology. Department of Physics
Ragon Institute of MGH, MIT and Harvard
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Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1007/s10955-011-0403-8
