Pd-Catalyzed Nucleophilic Fluorination of Aryl Bromides
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Lee-2014-Pd-catalyzed.pdf
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Author(s)
Lee, Hong Geun
Milner, Phillip John
Buchwald, Stephen Leffler
Date Issued
March 2014
Journal
Journal of the American Chemical Society
Publisher
American Chemical Society (ACS)
Citation
Lee, Hong Geun, Phillip J. Milner, and Stephen L. Buchwald. “Pd-Catalyzed Nucleophilic Fluorination of Aryl Bromides.” Journal of the American Chemical Society 136, no. 10 (March 12, 2014): 3792–3795. © 2014 American Chemical Society.
Version
Final published version
Abstract
On the basis of mechanism-driven reaction design, a Pd-catalyzed nucleophilic fluorination of aryl bromides and iodides has been developed. The method exhibits a broad substrate scope, especially with respect to nitrogen-containing heteroaryl bromides, and proceeds with minimal formation of the corresponding reduction products. A facilitated ligand modification process was shown to be critical to the success of the reaction.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1021/ja5009739
