Cellular expression through morphogen delivery by light activated magnetic microrobots
Name
12213_2019_119_ReferencePDF.pdf
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4.03 MB
Format
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Checksum (MD5)
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Author(s)
Das, Sambeeta
Hunter, Elizabeth E.
DeLateur, Nicholas Andrew
Steager, Edward B.
Weiss, Ron
Kumar, Vijay
Date Issued
June 2019
Journal
Journal of Micro-Bio Robotics
Publisher
Springer Science and Business Media
Citation
Das, Sambeeta et al. "Cellular expression through morphogen delivery by light activated magnetic microrobots." Journal of Micro-Bio Robotics 15, 2 (June 2019): 79–90 © 2019 Springer-Verlag
Version
Author's final manuscript
Abstract
Microrobots have many potential uses in microbiology since they can be remotely actuated and precisely manipulated in biochemical fluids. Cellular function and response depends on biochemicals. Therefore, various delivery methods have been developed for delivering biologically relevant cargo using microrobots. However, localized targeting without payload leakage during transport is challenging. Here, we design a microrobotic platform capable of on-demand delivery of signaling molecules in biological systems. The on-demand delivery method is based on a light-responsive photolabile linker which releases a cell-to-cell signaling molecule when exposed to light, integrated on the surface of microrobots. Successful delivery of the signaling molecules and subsequent gene regulation is also demonstrated. This proposed method can be used for multiple applications, especially in biology, engineering, and medicine where on-demand delivery of chemical cargo at targeted locations is important.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Massachusetts Institute of Technology. Department of Biological Engineering
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1007/s12213-019-00119-x
