Cell Microenvironment Engineering and Monitoring for Tissue Engineering and Regenerative Medicine: The Recent Advances
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2738.2014.921905.pdf
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3.16 MB
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0dc84f84bd572613fd66700fdb283555
Author(s)
Barthes, Julien
Ozcelik, Hayriye
Hindie, Mathilde
Ndreu-Halili, Albana
Hasan, Anwarul
Vrana, Nihal Engin
Date Issued
July 2014
Journal
BioMed Research International
Publisher
Hindawi Publishing Corporation
Citation
Barthes, Julien, Hayriye Ozcelik, Mathilde Hindie, Albana, Ndreu-Halili, Anwarul Hasan, Nihal Engin Vrana. Cell Microenvironment Engineering and Monitoring for Tissue Engineering and Regenerative Medicine: The Recent Advances. BioMed Research International, Volume 2014 (2014), Article ID 921905, 18 pages
Version
Author's final manuscript
Abstract
In tissue engineering and regenerative medicine, the conditions in the immediate vicinity of the cells have a direct effect on cells’ behaviour and subsequently on clinical outcomes. Physical, chemical, and biological control of cell microenvironment are of crucial importance for the ability to direct and control cell behaviour in 3-dimensional tissue engineering scaffolds spatially and temporally. In this review, we will focus on the different aspects of cell microenvironment such as surface micro-, nanotopography, extracellular matrix composition and distribution, controlled release of soluble factors, and mechanical stress/strain conditions and how these aspects and their interactions can be used to achieve a higher degree of control over cellular activities. The effect of these parameters on the cellular behaviour within tissue engineering context is discussed and how these parameters are used to develop engineered tissues is elaborated. Also, recent techniques developed for the monitoring of the cell microenvironment in vitro and in vivo are reviewed, together with recent tissue engineering applications where the control of cell microenvironment has been exploited. Cell microenvironment engineering and monitoring are crucial parts of tissue engineering efforts and systems which utilize different components of the cell microenvironment simultaneously can provide more functional engineered tissues in the near future.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
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DOI of Published Version
https://doi.org/10.1155/2014/921905
