Heritability in the genome-wide association era
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439_2012_Article_1199.pdf
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Author(s)
Zaitlen, Noah
Kraft, Peter
Date Issued
July 2012
Journal
Human Genetics
Publisher
Springer-Verlag
Citation
Zaitlen, Noah, and Peter Kraft. “Heritability in the Genome-Wide Association Era.” Human Genetics 131.10 (2012): 1655–1664.
Version
Author's final manuscript
Abstract
Heritability, the fraction of phenotypic variation explained by genetic variation, has been estimated for many phenotypes in a range of populations, organisms, and time points. The recent development of efficient genotyping and sequencing technology has led researchers to attempt to identify the genetic variants responsible for the genetic component of phenotype directly via GWAS. The gap between the phenotypic variance explained by GWAS results and those estimated from classical heritability methods has been termed the “missing heritability problem”. In this work, we examine modern methods for estimating heritability, which use the genotype and sequence data directly. We discuss them in the context of classical heritability methods, the missing heritability problem, and describe their implications for understanding the genetic architecture of complex phenotypes.
MIT Department
Broad Institute of MIT and Harvard
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1007/s00439-012-1199-6
