Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak
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Lander_Genomic surveillance + figures.pdf
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1.46 MB
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Adobe PDF
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70e19e72c66425808ddf22abb40c8281
Author(s)
Sealfon, Rachel Sima
Lander, Eric Steven
Date Issued
August 2014
Journal
Science
Publisher
American Association for the Advancement of Science (AAAS)
Citation
Gire, S. K., A. Goba, K. G. Andersen, R. S. G. Sealfon, D. J. Park, L. Kanneh, S. Jalloh, et al. “Genomic Surveillance Elucidates Ebola Virus Origin and Transmission During the 2014 Outbreak.” Science 345, no. 6202 (August 28, 2014): 1369–1372.
Version
Author's final manuscript
Abstract
In its largest outbreak, Ebola virus disease is spreading through Guinea, Liberia, Sierra Leone, and Nigeria. We sequenced 99 Ebola virus genomes from 78 patients in Sierra Leone to ~2000× coverage. We observed a rapid accumulation of interhost and intrahost genetic variation, allowing us to characterize patterns of viral transmission over the initial weeks of the epidemic. This West African variant likely diverged from central African lineages around 2004, crossed from Guinea to Sierra Leone in May 2014, and has exhibited sustained human-to-human transmission subsequently, with no evidence of additional zoonotic sources. Because many of the mutations alter protein sequences and other biologically meaningful targets, they should be monitored for impact on diagnostics, vaccines, and therapies critical to outbreak response.
MIT Department
Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Massachusetts Institute of Technology. Department of Biology
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1126/science.1259657
