SIRT1 and other sirtuins in metabolism
Name
Guarente_SIRT1 and other.pdf
Size
1.23 MB
Format
Adobe PDF
Checksum (MD5)
9af1b4a51162f9d1ba176e04bd829418
Author(s)
Chang, Hung-Chun
Guarente, Leonard Pershing
Date Issued
March 2014
Journal
Trends in Endocrinology & Metabolism
Publisher
Elsevier
Citation
Chang, Hung-Chun, and Leonard Guarente. “SIRT1 and Other Sirtuins in Metabolism.” Trends in Endocrinology & Metabolism 25, no. 3 (March 2014): 138-145.
Version
Author's final manuscript
Abstract
Sirtuins such as SIRT1 are conserved protein NAD[superscript +]-dependent deacylases and thus their function is intrinsically linked to cellular metabolism. Over the past two decades, accumulating evidence has indicated that sirtuins are not only important energy status sensors but also protect cells against metabolic stresses. Sirtuins regulate the aging process and are themselves regulated by diet and environmental stress. The versatile functions of sirtuins including, more specifically, SIRT1 are supported by their diverse cellular location allowing cells to sense changes in energy levels in the nucleus, cytoplasm, and mitochondrion. SIRT1 plays a critical role in metabolic health by deacetylating many target proteins in numerous tissues, including liver, muscle, adipose tissue, heart, and endothelium. This sirtuin also exerts important systemic effects via the hypothalamus. This review will cover these topics and suggest that strategies to maintain sirtuin activity may be on the horizon to forestall diseases of aging.
Description
Available in PMC 2015 March 01.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Paul F. Glenn Center for Biology of Aging Research (Massachusetts Institute of Technology)
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.tem.2013.12.001
