Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes
Name
11745.full.pdf
Size
1.34 MB
Format
Adobe PDF
Checksum (MD5)
a3c114eb27d1b42a840c55abf87245dd
Author(s)
Ludwig, Barbara
Ludwig, Stefan
Steffen, Anja
Knauf, Yvonne
Zimerman, Baruch
Heinke, Sophie
Lehmann, Susann
Schubert, Undine
Schmid, Janine
Bleyer, Martina
Date Issued
October 2017
Journal
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences (U.S.)
Citation
Ludwig, Barbara et al. “Favorable Outcome of Experimental Islet Xenotransplantation Without Immunosuppression in a Nonhuman Primate Model of Diabetes.” Proceedings of the National Academy of Sciences 114, 44 (October 2017): 11745–11750 © 2017 National Academy of Sciences
Version
Final published version
Abstract
Transplantation of pancreatic islets for treating type 1 diabetes is restricted to patients with critical metabolic lability resulting from the need for immunosuppression and the shortage of donor organs. To overcome these barriers, we developed a strategy to macroencap-sulate islets from different sources that allow their survival and function without immunosuppression. Here we report successful and safe transplantation of porcine islets with a bioartificial pancreas device in diabetic primates without any immune suppression. This strategy should lead to pioneering clinical trials with xenotransplantation for treatment of diabetes and, thereby, represents a previously unidentified approach to efficient cell replacement for a broad spectrum of endocrine disorders and other organ dysfunctions. Keywords: diabetes; porcine islets; beta-cell replacement; immune barrier
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1073/PNAS.1708420114
