Realistic wave-optics simulation of X-ray phase-contrast imaging at a human scale
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Sung-2015-Realistic wave-optics.pdf
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Author(s)
Sung, Yongjin
Segars, W. Paul
Pan, Adam
Ando, Masami
Sheppard, Colin J. R.
Gupta, Rajiv
Date Issued
July 2015
Journal
Scientific Reports
Publisher
Nature Publishing Group
Citation
Sung, Yongjin, W. Paul Segars, Adam Pan, Masami Ando, Colin J. R. Sheppard, and Rajiv Gupta. “Realistic Wave-Optics Simulation of X-Ray Phase-Contrast Imaging at a Human Scale.” Scientific Reports 5 (July 14, 2015): 12011.
Version
Final published version
Abstract
X-ray phase-contrast imaging (XPCI) can dramatically improve soft tissue contrast in X-ray medical imaging. Despite worldwide efforts to develop novel XPCI systems, a numerical framework to rigorously predict the performance of a clinical XPCI system at a human scale is not yet available. We have developed such a tool by combining a numerical anthropomorphic phantom defined with non-uniform rational B-splines (NURBS) and a wave optics-based simulator that can accurately capture the phase-contrast signal from a human-scaled numerical phantom. Using a synchrotron-based, high-performance XPCI system, we provide qualitative comparison between simulated and experimental images. Our tool can be used to simulate the performance of XPCI on various disease entities and compare proposed XPCI systems in an unbiased manner.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
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Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.1038/srep12011
