Light microscopy mapping of connections in the intact brain
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Chung_Light with SI.pdf
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Author(s)
Kim, Sung-Yon
Chung, Kwanghun
Deisseroth, Karl
Date Issued
November 2013
Journal
Trends in Cognitive Sciences
Publisher
Elsevier
Citation
Kim, Sung-Yon, Kwanghun Chung, and Karl Deisseroth. “Light Microscopy Mapping of Connections in the Intact Brain.” Trends in Cognitive Sciences 17, no. 12 (December 2013): 596–599.
Version
Author's final manuscript
Abstract
Mapping of neural connectivity across the mammalian brain is a daunting and exciting prospect. Current approaches can be divided into three classes: macroscale, focusing on coarse inter-regional connectivity; mesoscale, involving a finer focus on neurons and projections; and microscale, reconstructing full details of all synaptic contacts. It remains to be determined how to bridge the datasets or insights from the different levels of study. Here we review recent light-microscopy-based approaches that may help in integration across scales.
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Massachusetts Institute of Technology. Department of Chemical Engineering
Picower Institute for Learning and Memory
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1016/j.tics.2013.10.005
