Unique features of a global human ectoparasite identified through sequencing of the bed bug genome
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Benoit-2016-Unique Features.pdf
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977.44 KB
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ebac7c45f82b29a96b2c6db92f908c6f
Author(s)
Waterhouse, Robert
Date Issued
February 2016
Journal
Nature Communications
Publisher
Nature Publishing Group
Citation
Benoit, Joshua B., Zach N. Adelman, Klaus Reinhardt, Amanda Dolan, Monica Poelchau, Emily C. Jennings, Elise M. Szuter, et al. “Unique Features of a Global Human Ectoparasite Identified through Sequencing of the Bed Bug Genome.” Nat Comms 7 (February 2, 2016): 10165.
Version
Final published version
Abstract
The bed bug, Cimex lectularius, has re-established itself as a ubiquitous human ectoparasite throughout much of the world during the past two decades. This global resurgence is likely linked to increased international travel and commerce in addition to widespread insecticide resistance. Analyses of the C. lectularius sequenced genome (650 Mb) and 14,220 predicted protein-coding genes provide a comprehensive representation of genes that are linked to traumatic insemination, a reduced chemosensory repertoire of genes related to obligate hematophagy, host–symbiont interactions, and several mechanisms of insecticide resistance. In addition, we document the presence of multiple putative lateral gene transfer events. Genome sequencing and annotation establish a solid foundation for future research on mechanisms of insecticide resistance, human–bed bug and symbiont–bed bug associations, and unique features of bed bug biology that contribute to the unprecedented success of C. lectularius as a human ectoparasite.
MIT Department
Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
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DOI of Published Version
https://doi.org/10.1038/ncomms10165
