Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles
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LIndquist_Overcoming fluconazole.pdf
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Author(s)
Youngsaye, Willmen
Dockendorff, Chris
Hartland, Cathy L.
Bittker, Joshua A.
Dandapani, Sivaraman
Palmer, Michelle
Whitesell, Luke
Lindquist, Susan
Schreiber, Stuart L.
Munoz, Benito
Date Issued
May 2012
Journal
Bioorganic & Medicinal Chemistry Letters
Publisher
Elsevier B.V.
Citation
Youngsaye, Willmen, Chris Dockendorff, Benjamin Vincent, Cathy L. Hartland, Joshua A. Bittker, Sivaraman Dandapani, Michelle Palmer, et al. “Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles.” Bioorganic & Medicinal Chemistry Letters 22, no. 9 (May 2012): 3362-3365.
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Author's final manuscript
Abstract
Continuing efforts to discover novel means of combating fluconazole resistance in Candida albicans have identified an indole derivative that sensitizes strains demonstrating resistance to fluconazole. This tetracycle (3, ML229) does not appear to act through established Hsp90 or calcineurin pathways to chemosensitize C. albicans, as determined in Saccharomyces cerevisiae models, and may be a useful probe to uncover alternative resistance pathways.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Whitehead Institute for Biomedical Research
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DOI of Published Version
https://doi.org/10.1016/j.bmcl.2012.02.035
