A Radical Role for TOR in Longevity
Name
Lamming-2011-A Radical Role for T.pdf
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178.02 KB
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Author(s)
Lamming, Dudley W.
Sabatini, David M.
Sabatini, David
Date Issued
June 2011
Journal
Cell Metabolism
Publisher
Elsevier
Citation
Lamming, Dudley W., and David M. Sabatini. “A Radical Role for TOR in Longevity.” Cell Metabolism 13, no. 6 (June 2011): 617–618. © 2011 Elsevier Inc.
Version
Final published version
Abstract
TOR (target of rapamycin) signaling regulates life span in many organisms, but the mechanism behind the effect is unknown. In this issue of Cell Metabolism, Pan and colleagues (2011) find that reduced TORC1 activity promotes yeast life span via a mechanism that, paradoxically, relies upon the production of normally deleterious reactive oxygen species.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Whitehead Institute for Biomedical Research
Koch Institute for Integrative Cancer Research at MIT
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1016/j.cmet.2011.05.006
