Reeling it in: how DNA topology drives loop extrusion by condensin
Name
nihms-1863200.pdf
Description
Accepted version
Size
268.21 KB
Format
Adobe PDF
Checksum (MD5)
d6f562caebed192198a303894d03198b
Author(s)
Narducci, Domenic N
Hansen, Anders S
Date Issued
2022
Journal
Nature Structural and Molecular Biology
Publisher
Springer Science and Business Media LLC
Citation
Narducci, Domenic N and Hansen, Anders S. 2022. "Reeling it in: how DNA topology drives loop extrusion by condensin." Nature Structural and Molecular Biology, 29 (7).
Version
Author's final manuscript
Abstract
Structural maintenance of chromosomes (SMC) complexes such as condensin regulate chromosome organization by extruding loops. A new study uses single-molecule imaging of condensin on supercoiled DNA to understand how condensins navigate the under- and overwound DNA states common throughout the genome.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1038/S41594-022-00805-8
