Regulation and Dysregulation of Chromosome Structure in Cancer
Name
Hnisz_Annual-Reviews_2017.pdf
Size
2.35 MB
Format
Adobe PDF
Checksum (MD5)
34f994ffff4d3e01173bd0d9728ecf8e
Author(s)
Hnisz, Denes
Schuijers, Jurian
Li, Charles Han
Young, Richard A.
Date Issued
March 2018
Journal
Annual Review of Cancer Biology
Citation
Hnisz, Denes et al. “Regulation and Dysregulation of Chromosome Structure in Cancer.” Annual Review of Cancer Biology 2, 1 (March 2018): 21–40 © 2018 Annual Reviews
Version
Author's final manuscript
Abstract
Cancer arises from genetic alterations that produce dysregulated gene expression programs. Normal gene regulation occurs in the context of chromosome loop structures called insulated neighborhoods, and recent studies have shown that these structures are altered and can contribute to oncogene dysregulation in various cancer cells. We review the types of genetic and epigenetic alterations that influence neighborhood structures and contribute to gene dysregulation in cancer, present models for insulated neighborhoods associated with the most prominent human oncogenes, and discuss how such models may lead to further advances in cancer diagnosis and therapy. Keywords: chromosome structure; insulated neighborhood; oncogene regulation
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1146/annurev-cancerbio-030617-050134
