Clinical validation of Wave-CAIPI susceptibility-weighted imaging for routine brain MRI at 1.5 T
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Author(s)
Conklin, John
Figueiro Longo, Maria G.
Tabari, Azadeh
Lio Goncalves Filho, Augusto
Liu, Wei
Splitthoff, Daniel N.
Lo, Wei-Ching
Cauley, Stephen F.
Setsompop, Kawin
Schaefer, Pamela W.
Date Issued
August 4, 2022
Journal
European Radiology
Publisher
Springer Berlin Heidelberg
Citation
Conklin, J., Figueiro Longo, M.G., Tabari, A. et al. Clinical validation of Wave-CAIPI susceptibility-weighted imaging for routine brain MRI at 1.5 T. Eur Radiol 32, 7128–7135 (2022).
Version
Author's final manuscript
Abstract
Abstract
Objectives
Wave-CAIPI (Controlled Aliasing in Parallel Imaging) enables dramatic reduction in acquisition time of 3D MRI sequences such as 3D susceptibility-weighted imaging (SWI) but has not been clinically evaluated at 1.5 T. We sought to compare highly accelerated Wave-CAIPI SWI (Wave-SWI) with two alternative standard sequences, conventional three-dimensional SWI and two-dimensional T2*-weighted Gradient-Echo (T2*w-GRE), in patients undergoing routine brain MRI at 1.5 T.
Methods
In this study, 172 patients undergoing 1.5 T brain MRI were scanned with a more commonly used susceptibility sequence (standard SWI or T2*w-GRE) and a highly accelerated Wave-SWI sequence. Two radiologists blinded to the acquisition technique scored each sequence for visualization of pathology, motion and signal dropout artifacts, image noise, visualization of normal anatomy (vessels and basal ganglia mineralization), and overall diagnostic quality. Superiority testing was performed to compare Wave-SWI to T2*w-GRE, and non-inferiority testing with 15% margin was performed to compare Wave-SWI to standard SWI.
Results
Wave-SWI performed superior in terms of visualization of pathology, signal dropout artifacts, visualization of normal anatomy, and overall image quality when compared to T2*w-GRE (all p < 0.001). Wave-SWI was non-inferior to standard SWI for visualization of normal anatomy and pathology, signal dropout artifacts, and overall image quality (all p < 0.001). Wave-SWI was superior to standard SWI for motion artifact (p < 0.001), while both conventional susceptibility sequences were superior to Wave-SWI for image noise (p < 0.001).
Conclusions
Wave-SWI can be performed in a 1.5 T clinical setting with robust performance and preservation of diagnostic quality.
Key Points
• Wave-SWI accelerated the acquisition of 3D high-resolution susceptibility images in 70% of the acquisition time of the conventional T2*GRE.
• Wave-SWI performed superior to T2*w-GRE for visualization of pathology, signal dropout artifacts, and overall diagnostic image quality.
• Wave-SWI was noninferior to standard SWI for visualization of normal anatomy and pathology, signal dropout artifacts, and overall diagnostic image quality.
MIT Department
Harvard-MIT Program in Health Sciences and Technology
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DOI of Published Version
https://doi.org/10.1007/s00330-022-08871-8
