Histone Deacetylases 1 and 2 in Memory Function
Name
HDAC Review_R1[62].pdf
Description
Accepted version
Size
783.11 KB
Format
Adobe PDF
Checksum (MD5)
10f1be1919b67f7ddd6bf514ef6e067a
Author(s)
Pao, Ping-Chieh
Tsai, Li-Huei
Date Issued
2022
Journal
ACS Chemical Neuroscience
Publisher
American Chemical Society (ACS)
Citation
Pao, Ping-Chieh and Tsai, Li-Huei. 2022. "Histone Deacetylases 1 and 2 in Memory Function." ACS Chemical Neuroscience, 13 (7).
Version
Author's final manuscript
Abstract
Histone deacetylases (HDACs) have been implicated in learning and memory, and their dysregulation has been linked to cognitive impairment in brain aging and neurodegenerative diseases. In this review, we focus on HDAC1 and HDAC2, highlighting recent progress on their roles in regulating brain function through distinct mechanisms, including gene repression and DNA repair pathways. Moreover, we discuss evidence demonstrating how HDAC1 and HDAC2 could be modulated and their potential as targets to combat memory deficits.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1021/ACSCHEMNEURO.1C00775
