Toward Imaging Biomarkers for Glycosaminoglycans
Name
Gray-2009-Toward Imaging Bioma.pdf
Size
1.16 MB
Format
Adobe PDF
Checksum (MD5)
ab2dddb63bd604438c659a1f0c363321
Author(s)
Gray, Martha L.
Date Issued
2009
Journal
Journal of Bone and Joint Surgery, American Volume
Publisher
Journal of Bone and Joint Surgery, Inc.
Citation
Gray, Martha L. “Toward Imaging Biomarkers for Glycosaminoglycans.” J Bone Joint Surg Am 91.Supplement_1 (2009): 44-49. © 2009 Journal of Bone and Joint Surgery, Inc.
Version
Final published version
Abstract
Advances in the diagnosis and treatment of cartilage degeneration will be accelerated with the availability of validated biomarkers that reveal the features relevant to the health of cartilage. Using the delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) technique for evaluating tissue glycosaminoglycan as a case study, I review the types of evidence needed to validate imaging (or other) biomarkers. In addition, I present discussions about face validity and technical validity and offer a review of emerging data that provide pathophysiologic validity. Examples of such data include evidence that glycosaminoglycan content is restored after an injury-induced loss and evidence suggesting that dGEMRIC can indicate when it is too late for protective (load-modifying) surgery. These and other data suggest that new imaging biomarkers may indeed be able to provide a state-of-cartilage proxy that can be of use in the diagnosis and staging of disease.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
http://dx.doi.org/10.2106/jbjs.h.01498
