Chemical biology of mutagenesis and DNA repair: cellular responses to DNA alkylation
Name
Nidhi Shrivastav-Revised submission pdf proof.pdf
Size
1.43 MB
Format
Adobe PDF
Checksum (MD5)
8db9ec659a26b8c0a4f01144f57b991c
Author(s)
Shrivastav, Nidhi
Li, Deyu
Essigmann, John M.
Date Issued
October 2009
Journal
Carcinogenesis
Publisher
Oxford University Press (OUP)
Citation
Shrivastav, N., D. Li, and J. M. Essigmann. “Chemical Biology of Mutagenesis and DNA Repair: Cellular Responses to DNA Alkylation.” Carcinogenesis 31.1 (2009): 59-70. Web. 15 Feb. 2012.
Version
Author's final manuscript
Abstract
The reaction of DNA-damaging agents with the genome results in a plethora of lesions, commonly referred to as adducts. Adducts may cause DNA to mutate, they may represent the chemical precursors of lethal events and they can disrupt expression of genes. Determination of which adduct is responsible for each of these biological endpoints is difficult, but this task has been accomplished for some carcinogenic DNA-damaging agents. Here, we describe the respective contributions of specific DNA lesions to the biological effects of low molecular weight alkylating agents.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Chemistry
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1093/carcin/bgp262
