Target-responsive DNA/RNA nanomaterials for microRNA sensing and inhibition: The jack-of-all-trades in cancer nanotheranostics?
Name
ADDReview paper Conde et al FINAL.pdf
Size
1.45 MB
Format
Adobe PDF
Checksum (MD5)
4912304c567ad678516bfa978b614317
Author(s)
Osorio De Castro Conde, Joao
Edelman, Elazer R
Artzi, Natalie
Date Issued
September 2014
Journal
Advanced Drug Delivery Reviews
Publisher
Elsevier BV
Citation
Conde, João et al. “Target-Responsive DNA/RNA Nanomaterials for microRNA Sensing and Inhibition: The Jack-of-All-Trades in Cancer Nanotheranostics?” Advanced Drug Delivery Reviews 81 (January 2015): 169–183 © 2014 Elsevier B.V.
Version
Author's final manuscript
Abstract
microRNAs (miRNAs) show high potential for cancer treatment, however one of the most significant bottlenecks in enabling miRNA effect is the need for an efficient vehicle capable of selective targeting to tumor cells without disrupting normal cells. Even more challenging is the ability to detect and silence multiple targets simultaneously with high sensitivity while precluding resistance to the therapeutic agents. Focusing on the pervasive role of miRNAs, herein we review the multiple nanomaterial-based systems that encapsulate DNA/RNA for miRNA sensing and inhibition in cancer therapy. Understanding the potential of miRNA detection and silencing while overcoming existing limitations will be critical to the optimization and clinical utilization of this technology. Keywords: microRNA; RNAi; Nanomaterials; Surface modification; Biosensors; Cancer; Nanotheranostics; Translational medicine
MIT Department
Institute for Medical Engineering and Science
Terms of Use
Creative Commons Attribution-Noncommercial-NoDerivatives
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.ADDR.2014.09.003
