Polyanhydride-Based Microparticles for Programmable Pulsatile Release of Diphtheria Toxoid (DT) for Single-Injection Self-Boosting Vaccines
Name
Advanced Materials - 2025 - Zhang - Polyanhydride‐Based Microparticles for Programmable Pulsatile Release of Diphtheria.pdf
Description
Published version
Size
4.63 MB
Format
Adobe PDF
Checksum (MD5)
d4ea6346ed7270ede502b04dbf40d49b
Author(s)
Zhang, Linzixuan
Xiao, Ruiqing
Gao, Wenhao
Garcia, Johnny
Pan, Xinyan
Daristotle, John L
Forster, Timothy
Han, Jooli
Chaddah, Mehr
Varshney, Dhruv
Date Issued
August 14, 2025
Journal
Advanced Materials
Publisher
Wiley
Citation
L. Zhang, R. Xiao, W. Gao, J. Garcia, X. Pan, J. L. Daristotle, T. Forster, J. Han, M. Chaddah, D. Varshney, N. Menon, K. J. McHugh, B. J. Pedretti, J. Y. Yeo, X. Yang, S. MacDonald, R. Langer, A. Jaklenec, Polyanhydride-Based Microparticles for Programmable Pulsatile Release of Diphtheria Toxoid (DT) for Single-Injection Self-Boosting Vaccines. Adv. Mater. 2025, 37, 2501168.
Version
Final published version
Abstract
Single‐Injection Self‐Boosting Vaccines A single‐injection platform for self‐boosting vaccines is developed using a polyanhydride‐based delivery system. The platform enables pulsatile antigen release, protects pH‐sensitive cargo, and elicits immune responses comparable to traditional multi‐dose regimens. Machine learning enhances design by accurately predicting release profiles, offering a promising solution to improve global vaccine coverage and reduce under‐immunization. More details can be found in article number 2501168 by Robert Langer, Ana Jaklenec, and co‐workers.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
Massachusetts Institute of Technology. Department of Biological Engineering
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Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.1002/adma.70086
