Genome sequence of the Asian Tiger mosquito, Aedes albopictus, reveals insights into its biology, genetics, and evolution
Name
Chen-2015-Genome sequence of t.pdf
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1.04 MB
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Author(s)
Chen, Xiao-Guang
Jiang, Xuanting
Gu, Jinbao
Xu, Meng
Wu, Yang
Deng, Yuhua
Zhang, Chi
Bonizzoni, Mariangela
Dermauw, Wannes
Vontas, John
Date Issued
November 2015
Journal
Proceedings of the National Academy of Sciences of the United States of America
Publisher
National Academy of Sciences (U.S.)
Citation
Chen, Xiao-Guang et al. “Genome Sequence of the Asian Tiger Mosquito, Aedes Albopictus , Reveals Insights into Its Biology, Genetics, and Evolution.” Proceedings of the National Academy of Sciences 112.44 (2015): E5907–E5915.
Version
Final published version
Abstract
The Asian tiger mosquito, Aedes albopictus, is a highly successful invasive species that transmits a number of human viral diseases, including dengue and Chikungunya fevers. This species has a large genome with significant population-based size variation. The complete genome sequence was determined for the Foshan strain, an established laboratory colony derived from wild mosquitoes from southeastern China, a region within the historical range of the origin of the species. The genome comprises 1,967 Mb, the largest mosquito genome sequenced to date, and its size results principally from an abundance of repetitive DNA classes. In addition, expansions of the numbers of members in gene families involved in insecticide-resistance mechanisms, diapause, sex determination, immunity, and olfaction also contribute to the larger size. Portions of integrated flavivirus-like genomes support a shared evolutionary history of association of these viruses with their vector. The large genome repertory may contribute to the adaptability and success of Ae. albopictus as an invasive species.
MIT Department
Broad Institute of MIT and Harvard
Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1073/pnas.1516410112
