Traditional Chinese Medicine and regulatory roles on epithelial-mesenchymal transitions
Name
13020_2019_Article_257.pdf
Size
1.37 MB
Format
Adobe PDF
Checksum (MD5)
b6060f39b2d7b9222721617933a77ce3
Author(s)
Bai, Jing
Kwok, Wee C
Thiery, Jean-Paul
Date Issued
September 23, 2019
Journal
Chinese Medicine
Publisher
BioMed Central
Citation
Bai, Jing, Wee C Kwok, and Jean-Paul Thiery. "Traditional Chinese Medicine and regulatory roles on epithelial-mesenchymal transitions." Chinese Medicine 14 (Sept. 2019): no. 34 doi 10.1186/s13020-019-0257-6 ©2019 Author(s)
Version
Final published version
Abstract
Epithelial–mesenchymal transition (EMT) is a critical biological process allowing epithelial cells to de-differentiate into mesenchymal cells. Orchestrated signaling pathways cooperatively induce EMT and effect physiological, sometimes pathological outcomes. Traditional Chinese Medicine (TCM) has been clinically prescribed for thousands of years and recent studies have found that TCM therapies can participate in EMT regulation. In this review, the historical discovery of EMT will be introduced, followed by a brief overview of its major roles in development and diseases. The second section will focus on EMT in organ fibrosis and tissue regeneration. The third section discusses EMT-induced cancer metastasis, and details how EMT contribute to distant dissemination. Finally, new EMT players are described, namely microRNA, epigenetic modifications, and alternative splicing. TCM drugs that affect EMT proven through an evidence-based research approach will be presented in each section.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
Creative Commons Attribution
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1186/s13020-019-0257-6
