Simple, efficient protocols for the Pd-catalyzed cross-coupling reaction of aryl chlorides and dimethylamine
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Author(s)
Lee, Brian K.
Biscoe, Mark R.
Buchwald, Stephen Leffler
Date Issued
March 2009
Journal
Tetrahedron Letters
Publisher
Elsevier
Citation
Lee, Brian K., Mark R. Biscoe, and Stephen L. Buchwald. “Simple, Efficient Protocols for the Pd-Catalyzed Cross-Coupling Reaction of Aryl Chlorides and Dimethylamine.” Tetrahedron Letters 50, no. 26 (July 2009): 3672–3674.
Version
Author's final manuscript
Abstract
Simple and efficient procedures for the Pd-catalyzed cross-coupling reaction of aryl chlorides and dimethylamine are described. At room temperature with a strong base, t-BuXPhos is employed as the supporting ligand; at 110 °C with a weak base, XPhos is employed as the supporting ligand. In each of these cases, commercially available solutions constitute the source of the dimethylamine, and recently disclosed precatalysts constitute the source of the ligand and Pd. This work further expands the utility of these precatalysts in reactions that benefit from an easily activated source of L[subscript 1]Pd(0).
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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DOI of Published Version
https://doi.org/10.1016/j.tetlet.2009.03.137
