Engineering and physical sciences in oncology: challenges and opportunities
Name
nihms915541.pdf
Description
Accepted version
Size
2.65 MB
Format
Adobe PDF
Checksum (MD5)
6c83ac57976dfd313d791cee7e2aff83
Author(s)
Mitchell, Michael J
Jain, Rakesh K.
Langer, Robert S
Date Issued
November 2017
Journal
Nature Reviews Cancer
Publisher
Springer Nature America, Inc
Citation
Mitchell, Michael J., Rakesh K. Jain, and Robert Langer. ."Engineering and physical sciences in oncology: challenges and opportunities." Nature Reviews Cancer 17,11 (November 2017):p.659–675. © 2017 Macmillan Publishers Limited.
Version
Author's final manuscript
Abstract
© 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. The principles of engineering and physics have been applied to oncology for nearly 50 years. Engineers and physical scientists have made contributions to all aspects of cancer biology, from quantitative understanding of tumour growth and progression to improved detection and treatment of cancer. Many early efforts focused on experimental and computational modelling of drug distribution, cell cycle kinetics and tumour growth dynamics. In the past decade, we have witnessed exponential growth at the interface of engineering, physics and oncology that has been fuelled by advances in fields including materials science, microfabrication, nanomedicine, microfluidics, imaging, and catalysed by new programmes at the National Institutes of Health (NIH), including the National Institute of Biomedical Imaging and Bioengineering (NIBIB), Physical Sciences in Oncology, and the National Cancer Institute (NCI) Alliance for Nanotechnology. Here, we review the advances made at the interface of engineering and physical sciences and oncology in four important areas: The physical microenvironment of the tumour and technological advances in drug delivery; cellular and molecular imaging; and microfluidics and microfabrication. We discussthe research advances, opportunities and challenges for integrating engineering and physical sciences with oncology to develop new methods to study, detect and treat cancer, and we also describe the future outlook for these emerging areas.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1038/NRC.2017.83
