Fatigue exhaustion of the mitral valve tissue
Name
10237_2018_1070_ReferencePDF.pdf
Size
7.56 MB
Format
Adobe PDF
Checksum (MD5)
5750c96c5fedb725da920ada5adffdd3
Author(s)
Javid, Farhad
Shahmansouri, Nastaran
Angeles, Jorge
Mongrain, Rosaire
Date Issued
August 2018
Journal
Biomechanics and Modeling in Mechanobiology
Publisher
Springer Science and Business Media LLC
Citation
Javid, Farhad et al. "Fatigue exhaustion of the mitral valve tissue." Biomechanics and Modeling in Mechanobiology 18, 1 (August 2018): 89–97 © 2018 Springer Nature
Version
Author's final manuscript
Abstract
Sudden failure and rupture of the tissue is a rare but serious short-term complication after the mitral valve surgical repair. Excessive cyclic loading on the suture line of the repair can progressively damage the surrounding tissue and finally cause tissue rupture. Moreover, mechanical over-tension, which occurs in a diseased mitral valve, gradually leads to tissue floppiness, mitral annular dilation, and leaflet rupture. In this work, the rupture mechanics of mitral valve is studied by characterizing the fracture toughness exhaustion of healthy tissue. Results of this study show that fracture toughness of the posterior mitral valve is lower than its anterior counterpart, indicating that posterior tissue is more prone to failure. Moreover, the decrease in fracture toughness by increasing the number of fatigue cycles shows that excessive mechanical loading leads to progressive failure and rupture of mitral valve tissue within a damage accumulative process.
MIT Department
Koch Institute for Integrative Cancer Research at MIT
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1007/s10237-018-1070-3
