Importance of Receptor-targeted Systems in the Battle Against Atherosclerosis
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Author(s)
Rosas, Elisabet
Sobenin, Igor
Orekhov, Alexander
Balcells-Camps, Mercedes
Edelman, Elazer R
Rosas, Elisabet Canyelles
Date Issued
2013
Journal
Current Pharmaceutical Design
Publisher
Bentham Science
Citation
Rosas, Elisabet, Igor Sobenin, Alexander Orekhov, Elazer Edelman, and Mercedes Balcells. “Importance of Receptor-Targeted Systems in the Battle Against Atherosclerosis.” Current Pharmaceutical Design 19, no. 33 (August 1, 2013): 5897–5903.
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Author's final manuscript
Abstract
Atherosclerosis is the leading cause of death in the Western World and has been for decades a field of intense research. Yet, while there is a rich and diverse literature describing in detail the players and mechanisms involved in this complex disease in cell and animal models, we remain today with virtually no reliable markers for early diagnosis and targeted treatments options. This review is centered upon the latter. We summarize the latest studies focused on detecting endothelial dysfunction during the early stages of atherosclerosis, when the disease is asymptomatic and describe strategies recently proposed to image and target advanced plaque.
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Harvard University--MIT Division of Health Sciences and Technology
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.2174/1381612811319330010
